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Cardiolin Supplement Facts |
||
|---|---|---|
| Serving Size: 1 Capsules Servings Per Container: 30 |
||
| Amount Per Serving | Daily Value | |
| Horse Chestnut Extract (Aesculus hippocastanum) (seed) | 250 mg | * |
| Butcher’s Broom Extract (Ruscus aculeatus) (root & stem) | 250 IU | * |
| Gotu Kola Extract (Centella asiatica) (herb) | 30 mg | * |
| Grape Seed Extract (Vitis vinifera) (seed) | 75 mcg | * |
| *Daily Value Not Established |
Daily Dosage: As a dietary supplement, take one capsule in the morning with 8 ounces of water. Our suggested minimum serving is 1 capsules daily/maximum serving of 2 capsules daily. 45-60 days of continuous use is necessary for optimum results.
Cardiolin Research:
Horse chestnut (Aesculus hippocastanum) - Horse chestnut affects both the collagen content and architecture of varicose veins and supports normal function of veins. It appears to relieve symptoms of CVI, which sometimes lead to varicose veins. The active component, aescin, exhibits anti-edematous, anti-inflammatory and venotonic properties (7). In an open study of 90 patients with CVI, it reduced leg and ankle circumference significantly and was well tolerated (8). Two reviews of clinical studies indicated that horse chestnut is effective in reducing leg size, pain and heaviness and can be comparable to compression stockings in decreasing leg volume in CVI (9,10).
Butcher's Broom (Ruscus aculeatus) - Butcher's broom has venotonic properties that reduce venous capacity and pooling of blood in the legs. It also has a protective effect on capillaries, vascular endothelium, and smooth muscle (11). In an open, multicenter study of a formula containing Ruscus aculeatus, hesperidin methyl chalcone and ascorbic acid given to 80 patients with CVI, the treatment showed a more rapid and complete regression of symptoms than those in the rutoside only group (12). A meta-analysis of trials involving this same product concluded that it significantly reduces the severity of the symptoms like edema, cramps and leg heaviness compared to placebo (13). Research suggests that cAMP levels are elevated in varicose veins and Ruscus may alter these levels (14).
Gotu kola (Centella asiatica) - Gotu kola has shown in clinical studies of CVI patients to increase the integrity of the tissue that supports veins, decrease lower leg edema and improve lower leg circulation (15,16). It appears to affect metabolism of the connective tissue in the vessel wall (17). Constituents like triterpenoids in gotu kola improve microcirculation and have been shown to be a safe treatment for reducing edema (18).
Grape seed (Vitis vinifera) - Extracts of grape seeds contain proanthocyanidins and procyanadins, which strengthen the connective tissue structure of blood vessels and have antioxidant effects (19,20). Clinical studies of an extract of Folia vitis viniferae in CVI showed significant improvements in the subjective feelings of heavy/tired legs, sensation of tension in the legs, tingling sensations in the legs and pain in the legs, as well as reductions in leg circumference and improved microvascular blood flow (21,22).
Cardiolin References:
- Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 2002 Apr;40(4):158-68.
- Petrassi C, Mastromarino A, Spartera C. PYCNOGENOL in chronic venous insufficiency. Phytomedicine 2000 Oct;7(5):383-8.
- Arcangeli P. Pycnogenol in chronic venous insufficiency. Fitoterapia 2000 Jun;71(3):236-44.
- Riccioni C et al. [Effectiveness of Troxerutin in association with Pycnogenol in the pharmacological treatment of venous insufficiency] Minerva Cardioangiol 2004 Feb;52(1):43-8.
- Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res 2002 Mar;16 Suppl 1:S1-5.
- Belcar G et al. Venous ulcers: microcirculatory improvement and faster healing with local use of pycnogenol((r)). Angiology 2005 Nov-Dec;56(6):699-705.
- Sirtori CR. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Pharmacol Res 2001 Sep;44(3):183-93.
- Dickson S et al. An open study to assess the safety and efficacy of Aesculus hippocastanum tablets (Aesculaforce 50mg) in the treatment of chronic venous insufficiency. J Herb Pharmacother 2004;4(2):19-32.
- Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd.
- Siebert U et al. Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studies. Int Angiol 2002 Dec;21(4):305-15.
- Cappelli R, Nicora M, Di Perri T. Use of extract of Ruscus aculeatus in venous disease in the lower limbs. Drugs Exp Clin Res 1988;14:277-83.
- Beltramino R, Penenory A, Buceta AM. An open-label, randomised multicentre study comparing the efficacy and safety of CYCLO 3 FORT versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Int Angiol 1999 Dec;18(4):337-42.
- Boyle P, Diehm C, Robertson C. Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency. Int Angiol 2003 Sep;22(3):250-62.
- Nemcova S et al. Cyclic nucleotides and production of prostanoids in human varicose veins. J Vasc Surg 1999 Nov;30(5):876-83.
- Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
- Cataldi A et al. [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency] Minerva Carioangiol 2001 Apr;49(2):159-63.
- Arpaia MR et al. Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins. Int J Clin Pharmacol Res 1990;10(4):229-33.
- Incandela L et al. Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy. Angiology 2001 Oct;52 Suppl 2:S9-13.
- Bombardelli E, Morazzoni P. Vitis vinifera L. Fitoterapia 1995;LXVI:291-317.
- Simonetti P et al. Procyanidins from Vitis vinifera seeds: in vivo effects on oxidative stress. J Agric Food Chem 2002 Oct 9;50(21):6217-21.
- Kalus U et al. Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R D 2004;5(2):63-71.
- Schaefer E et al. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschung 2003;53(4):243-6.
